Novel planar chiral P,N-[2.2]paracyclophane ligands: synthesis and application in palladium-catalyzed allylic alkylation |
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| Institution: | 1. State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China |
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| Abstract: | A series of planar chiral P,N-2.2]paracyclophane ligands were synthesized and applied in enantioselective palladium-catalyzed allylic alkylation, in which the central chirality of 2.2]paracyclophane is the dominant stereocontrol element. The effect of the substituents attached to the phosphorus atom of these ligands on the yield and stereoselectivity of the reaction was also investigated. |
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