Synthesis of optically active methadones,LAAM and bufuralol by lipase-catalysed acylations |
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| Affiliation: | 1. Ultrafine, UFC Ltd., Synergy House, Guildhall Close, Manchester Science Park, Manchester M15 6SY, UK;2. Department of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland, UK;1. Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan;2. Department of Urology, Sendai City Hospital, Sendai, Japan;3. Miyagi Cancer Society, Sendai, Japan;4. Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan;1. Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA;2. Dept. of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt;3. Department of Chemistry, Wake Forest University, Winston Salem, NC, USA |
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| Abstract: | (R)- and (S)-Methadones and levo-α-acetylmethadol (LAAM) have been synthesised starting from lipase-catalysed acylation of dimethylaminopropan-2-ol. An approach to the synthesis of (R)-bufuralol is also presented. |
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