Enantioselective hydrogenation catalyzed by highly active rhodium complexes of chiral phosphites with atropisomeric moieties |
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| Affiliation: | 1. Department of Organic Chemistry, University of Veszprém, H-8201 Veszprém, Hungary;2. Research Group for Petrochemistry, Hungarian Academy of Science, PO Box 158, H-8201 Veszprém, Hungary;3. Department of General and Analytical Chemistry, Technical University of Budapest, H-1521 Budapest, Hungary;4. Degussa AG, Projecthause Catalyse, Industriepark Höchst, Building G830, D-65926 Frankfurt a. M., Germany;1. Max Planck Institute for Chemical Energy Conversion, Stiftstrasse 34, 45470 Mülheim an der Ruhr, Germany;2. Department of Bio- and Chemical Engineering, Laboratory of Industrial Chemistry, Technical University of Dortmund, Emil-Figge-Straße 66, 44227 Dortmund, Germany;1. Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan;2. JST, ACT-C, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan;1. MTA-PTE Research Group for Selective Chemical Syntheses, Ifjúság u. 6, H-7624, Pécs, Hungary;2. Department of Inorganic Chemistry, University of Pécs and Szentágothai Research Centre, PO Box 266, H-7624, Pécs, Hungary |
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| Abstract: | Excellent ee's and extremely high activities are obtained in the rhodium-catalyzed hydrogenation of dimethyl itaconate using simple and readily available H8-BINOL based monodentate phosphites. The hydrogenation proceeds efficiently even at a substrate concentration of 5.263 mol L−1 and at a substrate to catalyst ratio (S/C) of 40,000 to give the product in 95.1% yield with up to 96.9% ee. |
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