| 具有肿瘤荧光成像性能的核壳纳米过氧化氢酶模拟物 |
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| 引用本文： | 杨 霞,陈秋云,宋京宝. 具有肿瘤荧光成像性能的核壳纳米过氧化氢酶模拟物[J]. 无机化学学报, 2012, 28(1): 164-170 |
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| 作者姓名： | 杨 霞 陈秋云 宋京宝 |
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| 作者单位： | 江苏大学化学化工学院,镇江,212013 |
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| 摘 要： | 运用微波法在硅核壳荧光材料的表面修饰了2-(二吡啶甲胺基)丙酸的锰配合物,获得具有荧光性能的锰-硅核壳纳米结构复合物,运用IR,UV,TEM等方法表征了纳米复合物的结构。H2O2岐化实验显示锰-硅核壳纳米复合物具有较好的过氧化氢酶模拟特性,是一种新的纳米过氧化氢酶模拟物。体外细胞荧光成像研究表明2-(二吡啶甲胺基)丙酸修饰的纳米球不能进入肿瘤细胞内,而锰-硅核壳纳米复合物能进入肿瘤细胞内,具备良好的肿瘤靶向性,显著提高肿瘤荧光成像效果,可作为新型的肿瘤成像剂。
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| 关 键 词： | 核壳纳米球 纳米复合物 成像 肿瘤 |
Tumor-Imaging Core-Shell Nano-Models for Catalase |
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| YANG Xi,CHEN Qiu-Yun and SONG Jing-Bao. Tumor-Imaging Core-Shell Nano-Models for Catalase[J]. Chinese Journal of Inorganic Chemistry, 2012, 28(1): 164-170 |
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| Authors: | YANG Xi CHEN Qiu-Yun SONG Jing-Bao |
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| Affiliation: | School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China,School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China and School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China |
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| Abstract: | Microwave synthesis approach has been developed for preparing Mn-silica core-shell nano-complexes with fluorescent imaging by assembling the Mn(Ⅱ) complexes of bis(2-pyridylmethyl)amino-2-propionic acid(Adpa) on the surface of silica core-shell nanoparticles.IR,UV,TEM were used to characterize the structure of nano-complexes.The results of H2O2 disproportionation show that Mn-silica core-shell nano-complexes have good analog characteristics of catalase as a new kind of nano-models for catalase.Cell fluorescence image in vitro indicates that these Adpa modified nanoparticles locate outside of tumor cells,in contrast,Mn-silica core-shell nano-complexes could enter tumor cells which enables simultaneous tumor-targeting and good fluorescent imaging as a new tumor imaging agent. |
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| Keywords: | core-shell nanosphere nano-complex imaging, cancer |
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