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Calix[4]arene N-chalconeamides: synthesis and influence on Mg2+,ATP-dependent Ca2+ accumulation in the smooth muscle subcellular structures |
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| Authors: | Mariia A Klyachina Vyacheslav I Boyko Anton V Yakovenko Lidiya G Babich Sergiy G Shlykov Sergiy O Kosterin Volodymyr P Khilya Vitaly I Kalchenko |
| Institution: | 1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kyiv-94, Murmanska Str., 5, Kyiv, 02660, Ukraine 2. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv-30, Leontovicha Str., 9, Kyiv, 01601, Ukraine 3. Kyiv Taras Shevchenko National University, Kyiv-33, Volodimirska Str., 60, Kyiv, 01033, Ukraine |
| Abstract: | The cone-shaped calixarene N-chalconeamides were synthesized by the reaction of calix4]arene carboxylic acids or acid chlorides with aminochalcones. It was found, that calixarene chalconeamides influence the Mg2+, ATP-dependent Ca2+ accumulation in mitochondria and sarcoplasmatic reticulum of the smooth muscle cells. |
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