Discrete assembly of synthetic peptide-DNA triplex structures from polyvalent melamine-thymine bifacial recognition |
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Authors: | Zeng Yingying Pratumyot Yaowalak Piao Xijun Bong Dennis |
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Institution: | Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA. |
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Abstract: | We have designed a 21-residue α-peptide that simultaneously recognizes two decadeoxyoligothymidine (dT(10)) tracts to form triplexes with a peptide-DNA strand ratio of 1:2. The synthetic peptide side chain displays 10 melamine rings, which provide a bifacial thymine-recognition interface along the length of the 21-residue peptide. Recognition is selective for thymine over other nucleobases and drives the formation of ternary peptide·dT(10)](2) complexes as well as heterodimeric peptide·dT(10)C(10)T(10)] hairpin structures with triplex stems. |
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