| 微波促进的5-氯-3-甲基-1-苯基-4-吡唑甲醛与氯化N-苯乙酮基吡啶及芳酰肼的缩合反应 |
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| 引用本文： | 张奉民,蔡习美,陈伟锋,颜朝国.微波促进的5-氯-3-甲基-1-苯基-4-吡唑甲醛与氯化N-苯乙酮基吡啶及芳酰肼的缩合反应[J].有机化学,2007,27(7):852-856. |
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| 作者姓名： | 张奉民 蔡习美 陈伟锋 颜朝国 |
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| 作者单位： | 扬州大学化学化工学院分析测试中心,扬州,225002 |
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| 基金项目： | 江苏省教育厅自然科学基金（No.04KJD150237）资助项目. |
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| 摘 要： | 5-氯-3-甲基-1-苯基-4-吡唑甲醛(1)在微波辐射下, 与氯化N-苯乙酮基吡啶(2)和取代苯乙酮3在醋酸铵/醋酸体系中一锅煮反应, 高产率地生成了吡唑基取代的吡啶衍生物4a～4e. 1与芳酰肼在微波辐射下反应, 则形成了酰腙类化合物6a～6g. 1与羟胺在微波辐射下缩合可生成肟7a和腈7b的混合物.
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| 关 键 词： | 微波辐射 缩合反应 吡啶 吡唑 酰腙 |
| 收稿时间： | 2006-5-29 |
| 修稿时间： | 2006-05-292006-10-17 |
Microwave Irradiated Condensation Reaction of 5-Chloro-3-methyl- 1-phenyl-4-pyrazolecarboaldehyde with N-Phenacylpyridinium Chloride and Acetophenone |
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| ZHANG Feng-Min,CAI Xi-Mei,CHEN Wei-Feng,YAN Chao-Guo.Microwave Irradiated Condensation Reaction of 5-Chloro-3-methyl- 1-phenyl-4-pyrazolecarboaldehyde with N-Phenacylpyridinium Chloride and Acetophenone[J].Chinese Journal of Organic Chemistry,2007,27(7):852-856. |
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| Authors: | ZHANG Feng-Min CAI Xi-Mei CHEN Wei-Feng YAN Chao-Guo |
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| Institution: | (Analytical Center, College of Chemistry & Chemical Engineering, Yangzhou 225002) |
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| Abstract: | In the system of ammonium acetate and acetic acid under microwave irradiation, 5-chloro-3- methyl-1-phenyl-4-pyrazolecarboaldehyde (1) reacted with N-phenacylpyridinium chloride (2) and acetophenone 3 to give pyrazolyl substituted pyridine 4a～4e in high yields. 1 reacted with some aromatic acylhydrazines 5 to give acylhydrazone derivatives 6a～6g, while reacted with hydroxyamine to give a mixture of oxime 7a and nitrile 7b. |
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| Keywords: | microwave irradiation condensation reaction pyridine pyrazole hydrazone |
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