An efficient synthesis of a new series of acyclonucleosides starting from beta-amino alcohols |
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Authors: | Agami C Dechoux L Hamon L Melaimi M |
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Institution: | Laboratoire de Synthèse Asymétrique (UMR CNRS 7611), Université P. et M. Curie, Paris, France. |
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Abstract: | A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from beta-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity. |
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