Isolation and Biomass Production of a <Emphasis Type="Italic">Saccharomyces cerevisiae</Emphasis> Strain Binding Copper and Zinc Ions |
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Authors: | Aurore Stroobants Jean-Marc Delroisse Franck Delvigne Julien Delva Daniel Portetelle Micheline Vandenbol |
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Institution: | (1) Unité de Biologie animale et microbienne, FUSAGx, Avenue Maréchal Juin, 6, 5030 Gembloux, Belgique;(2) Unité de Bio-industries, FUSAGx, Passage des Déportés, 2, 5030 Gembloux, Belgium;(3) Département “Sciences et Gestion de l’Environnement”, ULg, Avenue de Longwy, 185, 6700 Arlon, Belgium |
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Abstract: | Copper and zinc are essential trace elements participating in many physiological functions, notably immunity and protection
against oxidative stress. Yeasts and the yeast Saccharomyces cerevisiae, in particular, possess in their genome tandem repeats of the CUP1 gene coding for a protein (a metallothionein) capable of capturing and binding toxic elements such as copper ions. The number
of copies of this gene in a cell determines its physiological level of resistance to these ions. This paper describes the
selection, characterization, and production of a new copper-resistant yeast strain that can bind large quantities of copper
and zinc. This approach should lead to increasing the bioavailability of these trace elements and hence to reducing their
emission into the environment. |
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Keywords: | Selection Metallothionein Probiotic Prebiotic Yeast CUP1 Bioreactor |
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