Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli |
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| Authors: | Fort Sébastien Birikaki Lemonia Dubois Marie-Pierre Antoine Tatiana Samain Eric Driguez Hugues |
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| Institution: | Centre de Recherches sur les Macromolécules Végétales, CERMAV-FR-CNRS 2607, affiliated to Université Joseph Fourier Grenoble, BP 53, 38041 Grenoble Cedex 9, France. Sebastien.Fort@cermav.cnrs.fr |
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| Abstract: | Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid. |
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