| Facile Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones Catalyzed by Ceric Ammonium Nitrate (CAN) under Ultrasound Irradiation |
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| 作者姓名： | WANG Shun-Yi
ZENG Xiao-Fei
ZHOU Wei-Juan
JI Shun-Jun |
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| 作者单位： | WANG,Shun-Yi（Key Laboratoy of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
ZENG,Xiao-Fei（Key Laboratoy of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
ZHOU,Wei-Juan（Key Laboratoy of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006）
JI,Shun-Jun（Key Laboratoy of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006） |
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| 摘 要： | Indole fragment is featured widely in a wide variety of pharmacologically and biologically active compounds.1] The 3,3-bis(3-indolyl)oxindole has been shown to possess antibiotic activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. 2] As a continue of our work on the synthesis of indole derivates such as bis(indolyl)methanes,3]we describe an ultrasound-accelerated reaction of isatin 1 with indoles 2 using a catalytic amount of ceric ammonium nitrate (CAN), which provides an efficient route to the synthesis of 3,3-di(1H-indol-3-yl)indolin-2-ones.
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Facile Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones Catalyzed by Ceric Ammonium Nitrate (CAN) under Ultrasound Irradiation |
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| WANG,Shun-Yi,ZENG,Xiao-Fei,ZHOU,Wei-Juan,JI,Shun-Jun.Facile Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones Catalyzed by Ceric Ammonium Nitrate (CAN) under Ultrasound Irradiation[J].Chinese Journal of Organic Chemistry,2004,24(Z1):262-263. |
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| Authors: | WANG Shun-Yi ZENG Xiao-Fei ZHOU Wei-Juan JI Shun-Jun |
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| Abstract: | Indole fragment is featured widely in a wide variety of pharmacologically and biologically active compounds.1] The 3,3-bis(3-indolyl)oxindole has been shown to possess antibiotic activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. 2] As a continue of our work on the synthesis of indole derivates such as bis(indolyl)methanes,3]we describe an ultrasound-accelerated reaction of isatin 1 with indoles 2 using a catalytic amount of ceric ammonium nitrate (CAN), which provides an efficient route to the synthesis of 3,3-di(1H-indol-3-yl)indolin-2-ones. |
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