Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe |
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| Authors: | Wei LI Wen YUAN Wei Jun JIN Chuan DONG |
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| Affiliation: | Wei LI1,2,Wen YUAN1,Wei Jun JIN1*,Chuan DONG1 1Department of Chemistry and 2Department of Environment Science Shanxi University,Taiyuan 030006 |
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| Abstract: | Anticancer drug Mitomycin C (MMC) quenches remarkably phosphorescence and reduces lifetime of phosphorescence probe, Pd-meso-tetrakis-(4-trimethylaminophenyl)porphin (Pd-TAPP), in the presence of calf thymus DNA. These results may be attributed to the site competition of MMC with the probe and electron transfer between MMC and probe. MMC also increases polarization degree of the probe by covalent drug-DNA or DNA-drug-DNA crosslinking. |
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| Keywords: | Phosphorescence probe mitomycin C ct-DNA. |
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