A Convenient Synthesis of Aminomethylphosphonic Acid |
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| Authors: | Mitchell J. Pulwer Terry M. Matthazor |
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| Affiliation: | Monsanto Agricultural Company , 800 N. Lindbergh Blvd., St. Louis, MO, 63167 |
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| Abstract: | A novel procedure for the preparation of aminometnylphosphonic acid (AMPA) is described. This compound. which has been shown to have some biological activity, is synthesized by treating N-hydroxymethylbenzamide with a mixture of phosphorous trichloride and trimethyl phosphite, followed by hydrolysis of the ester intermediate. |
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