(S)-2-Amino-3-(2,5-dimethylphenyl)-1,1-diphenyl-1-propanol: Synthesis and Application in Enantioselective Reduction of Prochiral Ketones |
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| Authors: | Ya-Wen Zhang Zong-Xuan Shen De-Ben Gu Wei-Yi Chen Zheng-Hao Fei Qing-Fei Dai |
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| Affiliation: | Department of Chemistry , Suzhou University , Suzhou, 215006, PR China |
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| Abstract: | The title chiral amino alcohol 6 was prepared from (s)-3-(2,5-dimethylphenyl)-alanine methyl ester hydrochloride by its reaction with phenyl magnesium bromide. In the presence of 2 mol% of 6, the borane reduction of prochiral ketones gave optically active secondary alcohols in high yields with the ee's ranged from 40.5 to 100%. |
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