A Practical Preparation of Thiol Carboxylic Esters of 2-(Isoxazolyl) Acetic Acids |
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| Authors: | Jaan A Pesti Jianguo Yin Jihchin Chung |
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| Institution: | The DuPont Pharmaceuticals Company, Chemical Process Research and Development , Experimental Station, Building E336, Wilmington, Delaware, 19880-0336 |
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| Abstract: | High yields of several thiolesters of 2-3-(4-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetic acid are easily prepared from the corresponding oxoester by the reaction with trimethyl silylated mercaptan and aluminum chloride. The selection of mercaptans expands the previous scope of this synthetic method. |
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