Chemoenzymatic Synthesis of (R)- and (S)-4-Amino-3-Methylbutanoic Acids |
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| Authors: | Ryszard Andruszkiewicz Anthony G. M. Barrett Richard B. Silverman |
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| Affiliation: | 1. Department of Chemistry and Department of Biochemistry , Molecular Biology, and Cell Biology, Northwestern University , Evanston, IL, 60208-3113;2. Department of Chemistry |
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| Abstract: | (R)- and (S)-4-Amino-3-methylbutanoic acids were synthesized in high yields via initial enantioselective hydrolysis of dimethyl 3-methylglutarate to methyl (R)-3-methylglutarate with pig liver esterase. The ester group was converted to an amine to give (R)-4-amino-3-methylbutanoic acid; the carboxylic acid was converted to an amine to give (S)-4-amino-3-methylbutanoic acid. |
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| Keywords: | Ring‐expanded Tiazofurin 2′,3′‐Dideoxynucleoside C‐Nucleosides Synthesis Conformation |
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