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An Efficient Synthesis of 3-Cyano-1(3H)-Isobehzofuranones |
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| Authors: | Kousuke Okazaki Keiichi Nomura Eiichi Yoshii |
| Institution: | Faculty of Pharmaceutical Sciences , Toyama Medical and Pharmaceutical University , Sugitani 2630, Toyama, 930-1, Japan |
| Abstract: | Reaction of o-formyl-N, N-diethylbenzamides (5) with trimethylsilyl cyanide affords the corresponding (0-trimethylsi-lyl)cyanohydrins (6), which on treatment with acetic acid produce 3-cyanophthalides (7) in 80–90% isolated yields. |
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