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A Short Synthesis of 1-Vinyluracil and 1-Vinylthymine |
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| Authors: | Jinglan Zhou Philip B. Shevlin |
| Affiliation: | Department of Chemistry , Auburn University , Auburn, AL, 36830 |
| Abstract: | 1-Vinyluracil and 1-vinylthymine, monomers for nucleic acid bases attached functional polymers, were synthesized for the first time from uracil and thymine in 3 steps in 54% and 50% overall yields using the Mitsunobu reactions of 2a and 2b with 2-chloroethanol as a key step. |
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