Regiospecific Synthesis of Dioxabicyclooctanes Containing a Terminal Prenyl Sidechain |
| |
| Authors: | Zoltan G. Hajos Michael P. Wachter Richard E. Adams Harvey M. Werblood |
| |
| Affiliation: | R. W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation , Raritan , New Jersey , 08869 |
| |
| Abstract: | A Wittig reaction employing the ylide generated from isopropyl triphenylphosphonium bromide with THP-protected aldol intermediate 8 constitutes the key step in a regiospecific synthesis of olefin 1 in the total synthesis of zoapatanol analogue 2a. |
| |
| Keywords: | Solvent-free 1,3,4-Thiadiazole Microwave irradiation |
|
