Design of the Synthesis of Steroidal 1,3,5(10),9(11)-Tetraenes via Isomerization of 1,3,5(10),8-Isomers - effect of the Solvent System |
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| Authors: | Li-Gong Liu Tong Zhang Zhen-Su Li |
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| Institution: | 1. Department of Chemistry , Central Queensland University , Rockhampton, Queensland, Australia , 4702;2. School of Pharmaceutical Sciences, Beijing Medical University , Beijing, 100083, P. R. China |
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| Abstract: | p-Toluenesulphonic acid catalytic isomerization of 1,3,5(10),8-tetraene steroids in benzene or toluene with the presence of acetic acid is established as a simple high-yield (85～89%) procedure to the synthesis of the corresponding 9(11)-isomers. The solvation effect is discussed for the design of the new reaction media. |
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