Polymer-Supported Bases. 10. Synthesis of Phosphatidylcholines Using Polymer-Supported or Free Acylimidazoles |
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| Authors: | Masao Tomoi Kiyoshi Inomata Hiroshi Kakiuchi Satoru Tokuyama |
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| Institution: | 1. Department of Applied Chemistry, Faculty of Engineering , Yokohama National University , Yokohama, 240, Japan;2. Tsukuba Research Laboratory , Nippon Oil &3. Fats Co. Ltd. , Ibaraki, 300-26, Japan |
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| Abstract: | Dipalmitoylphosphatidylcholine was synthesized in a good yield by the reaction of L-α-glycerophosphorylcholine with 1-palmitoylimidazole in the presence of DBU. Polymer-supported 1-palmitoylimidazole moiety also could be used as the acylating reagent, though the yield of the choline was moderate. |
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