Crystallization Induced Asymmetric Transformation: Synthesis of D-p-Hydroxyphenylglycine |
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| Authors: | Apurba Bhattacharya Carina Araullo-Mcadams Michael B Meier |
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| Affiliation: | Hoechst Celanese Corporation, Corpus Christi Technical Center , P. O. Box 9077, Corpus Christi, Texas, 78469, U.S.A. |
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| Abstract: | D-p-hydroxyphenylglycine (D-HPG) is prepared from racemic HPG via salicylaldehyde mediated resolution-racemization of the corresponding D-3-bromocamphor-8-sulfonate salt in acetic acid. After slurry purification to improve the de to >99.9%, the crystallized salt is neutralized to produce D-HPG in 92% overall yield and 99.9% ee. |
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