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A Practical Synthesis of 2-Butyl-4(5)-chloro-5(4)-hydroxymethyl- 1H-imidazole |
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| Authors: | Yao-Jun Shi Lisa F. Frey David M. Tschaen Thomas R. Verhoeven |
| Affiliation: | Department of Process Research , Merck Research Laboratory , P.O. Box 2000, Rahway, New Jersey, 07065 |
| Abstract: | A practical process for the synthesis of 2-butyl-4-hydroxymethyl imidazole (4) followed by chlorination to provide chloroimidazole 1 in an overall 71% yield has been developed. |
| Keywords: | |