A Simple Synthesis of 2′,5′-Disubstituted-Spiro [Dihydroacridine 9(10H), 4′-Thiazolines] by the Reaction of Corresponding 3-(Acridin-9-Yl)-Thioureas with Methyl Bromoacetate and Bromoacetonitrile |
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| Authors: | Juraj Bernát Igor Chomča Pavol Kristian Gundula Voss |
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| Institution: | 1. Department of Organic Chemistry , P.J. ?afarik University , SK-041 67, Ko?ice, Slovakia;2. Department of Organic Chemistry , Bayreuth University , D-954 47, Bayreuth, Germany |
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| Abstract: | A convenient method has been devised for the preparation of the spirodihydro-acridinethiazolines 5a-j by the treatment of thioureas 3a-e with methyl bromoacetate and bromoacetonitrile via non-isolable isothioureas 4a-j and their subsequent cyclization with methanolic sodium methoxide. |
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| Keywords: | isothiocyanatoacridine acridinylthiourea spirodihydroacridinethiazoline |
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