A Rapid and Efficient Method for Dehydration of Primary Amides to Nitriles. Preparation of Acrylonitrile Derivatives |
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| Authors: | T M Bargar C M Riley |
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| Institution: | 1. The Procter &2. Gamble Co., Miami Valley Laboratories , Cincinnati, Ohio, 45247 |
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| Abstract: | Chloromethylene iminium salts (Vilsmeier reagents) have a long history and thoroughly investigated chemistry(1). Chloro-N, N-dimethylforminium chloride 1 is most conveniently generated by the reaction of N, N-dimethylformamide (DMF) with oxalyl chloride(2). The reagent has also been obtained using 1 or a related species is thought to function as the reactive intermediate in the transformation of amides to nitriles(3). |
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