Alkylation of Tetrazoles Using Mitsunobu Conditions |
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| Authors: | Claude F Purchase II Andrew D White |
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| Institution: | Department of Medicinal Chemistry , Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company , Ann Arbor, Michigan, 48105 |
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| Abstract: | The alkylation of tetrazoles using Mitsunobu conditions and alcohols is reported. The methodology is superior to the base-promoted reaction with alkyl halides for the installation of a secondary alkyl group because it results in higher yields and facilitates the construction of chiral centers bearing tetrazole. |
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