Incorporation of an Amino Function in a (1S,2S,3R)-3-Hydroxy-2-methoxy-1-cyclohexane Carboxylic Acid |
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| Authors: | Scott C. Mayer Madeleine M. Joullié |
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| Affiliation: | Department of Chemistry , University of Pennsylvania , Philadelphia, Pennsylvania, 19104-6323 |
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| Abstract: | (1S,2S,3R)-3-Hydroxy-2-methoxy-1-cyclohexanecarboxylic acid was synthesized for the construction of an amino acid to be used in a constrained ring didemnin B analog ( 2 ). The amine functionality was introduced into the cyclohexane ring by reductive amination using sodium triacetoxyborohydride or by oxime formation followed by reduction. |
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