The Regioselective 4-Benzylation of 2,4-Dihydroxybenzaldehyde |
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| Authors: | Wilford L. Mendelson Monica Holmes Jack Dougherty |
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| Affiliation: | 1. Synthetic Chemistry Department , SmithKline Beecham Pharmaceuticals , Post Office Box 1539, King of Prussia, PA, 19406–0939;2. Analytical Chemistry Department , SmithKline Beecham Pharmaceuticals , Post Office Box 1539, King of Prussia, PA, 19406–0939 |
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| Abstract: | A regioselective mono-benzylation of the 4-hydroxyl group of 2,4-dihydroxybenzaldehyde (2) to produce 1 under extremely mild basic conditions (NaHCO3 or KF) has been developed. This approach gives improved regioselectivity relative to earlier methods. |
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