Reaction of Mercaptoacetate and Halides Containing Activated Methylenes with Thiocarbamoylimidates: A Novel Approach to the Synthesis of Aminothiazole Derivatives |
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| Authors: | K Dridi M L EL Efrit B Baccar H Zantour |
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| Institution: | Laboratoire de Synthèse Organique, Département de Chimie, Faculté des Sciences , Campus Universitaire , 1060, Tunis-Tunisie |
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| Abstract: | The reaction of N-thiocarbamoylimidates 1 with methyl thioglycolate leads to the formation of 4-arylamino-5-methoxycarbonylthiazoles 2. The condensation of the same imidates 1 on ethyl bromoacetate, benzyl bromide and chloroacetonitrile provides the corresponding 2-arylaminothiazoles 4. |
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| Keywords: | Aluminum trifluromethanesulfonate Carbonyl compounds Catalyst Chemoselective Solvent-free Thioacetalization |
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