Synthesis of the Dopamine Agonist (-)-Quinpirole |
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Authors: | John M. Schaus Diane L. Huser Robert D. Titus |
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Affiliation: | Lilly Research Laboratories Eli Lilly and Company , Indianapolis, IN, 46285 |
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Abstract: | A convenient synthesis and resolution of (-)-trans-4aR,8aR-1-propyl-6-oxo-decahydroquinoline (4) is described. This compound is then converted into the D-2 selective dopamine agonist, (-)-quinpirole hydrochloride (3). |
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