Intramolecular Baylis-Hillman Reaction: A Pathway to Substituted Coumarins |
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| Authors: | Siegfried E. Drewes Owen L. Njamela Neville D. Emslie Niyum Ramesar John S. Field |
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| Affiliation: | Department of Chemistry , University of Natal , P O Box 375, Pietermaritzburg, 3200, South Africa |
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| Abstract: | The acrylate ester of salicylaldehyde, in the presence of DABCO, affords a crystalline coumarin salt. Formation of this derivative confirms a vital intermediate in the mechanism of the reaction. Salicylaldehyde, suitably protected, reacts with methyl acrylate to afford a novel coumarin not unlike the vasodilator chromonar. |
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