A Convenient Preparation of 8-Ethyl-4,9-dihydro-3H-pyrano[3,4-b]indole-1-one,Key Intermediate of the Antiinflammatory Agent Etodolac |
| |
| Authors: | Asensio González |
| |
| Affiliation: | Laboratory of Organic Chemistry, Faculty of Pharmacy , University of Barcelona , 08028, Barcelona, Spain |
| |
| Abstract: | A facile synthesis of 8-ethyl-4,9-dihydro-3H-pyrano [3,4-b]indole-1-one 5 is described which features the condensation of hydrazines with 2-oxo-5-hydroxypentanoic acid, followed by Fischer Cyclization of these adducts. |
| |
| Keywords: | Pseudohalogenation pseudohalophosphates pseudohalides phosphorochloridates phase transfer catalyst |
|
|
