A Convenient Synthesis of N-Alkyl and N,N-Dialkyltrifluoroacetamides in a Solid-liquid Two-Phase System in the Presence of Phase-Transfer Catalysts |
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| Authors: | Dario Landini Michele Penso |
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| Affiliation: | Centro C.N.R. e Dipartimento di Chimica , Organica e Industriale dell'Universitè , Via C. Golgi 19, Milano, 1-20133, Italy |
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| Abstract: | Trifluoroacetamide is easily monoalkylated in a K2 CO3-organic solvent solid-liquid two-phase system affording in good to excellent yields N-alkyltrifluoroacetamides. Under the same conditions, the latter, in turn, react with alkylating agents giving N, N-dialkyltrifluoroacetamides in high yields. |
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