Ketene-S,N-Acetals As Synthetic Intermediates of Heterocycles. New Synthesis of Uracil and Barbituric Acid Derivatives |
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| Authors: | Hiroki Takahata Tomoko Nakajima Takao Yamazaki |
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| Affiliation: | Faculty of Pharmaceutical Sciences , Toyama Medical and Pharmaceutical University , 2630 Sugitani, Toyama, 930-01, Japan |
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| Abstract: | The importance of enamines for organic synthesis is well documented.1 Ketene-S,N-acetals2 derived from tertiary thioamides are α-alkylthiosubstituted enamines and expected to work as the synthetic equivalent of an enolate anion3. We have been interested in exploring their synthetic utility as the intermediates of heterocycles.4 |
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