Reductive Amination with Zinc Borohydride. Efficient,Safe Route to Fluorinated Benzylamines |
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| Authors: | Sukanta Bhattacharyya Arindam Chatterjee John S Williamson |
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| Institution: | 1. Department of Chemistry , The University of Mississippi University , MS, 38677 , USA;2. Department of Medicinal Chemistry , School of Pharmacy, The University of Mississippi, University , MS, 38677 , USA |
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| Abstract: | Abstract: Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations. |
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