Improved Preparation of 5-Chloro-1-phenyl-1H-tetrazole and Other 5-Chlorotetrazoles. |
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| Authors: | José A C Alves Robert A W Johnstone |
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| Institution: | Department of Chemistry , University of Liverpool , Liverpool , L69 3BX , U.K. |
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| Abstract: | Reaction of aryldichloroisocyanides 1a–e with sodium azide and a phase transfer agent has provided 5-chloro-1-aryl-1H-tetrazoles 2a–e in good yield. In particular, the widely-used intermediate, 5-chloro-1-phenyl-1H-tetrazole 2a, can be produced conveniently and safely in yields approaching 100%. |
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