An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-Difluorosalicylic Acid # |
| |
| Authors: | Michele A Weidner-Wells Stephanie A Fraga-Spano |
| |
| Institution: | Drug Discovery, The R.W. Johnson Pharmaceutical Research Institute , 1000 Route 202, Raritan, N.J., 08869 |
| |
| Abstract: | An improved method for the synthesis of 3,5-difluorosalicylic acid (3b) and 3,5-difluorosalicylaldehyde (3a) is described. 2,4-Difluorophenol (4) undergoes a formylation reaction to afford aldehyde 3a which is oxidized to the desired acid 3b. This method avoids the use of the highly corrosive HF and fluorine gas and requires no special laboratory apparatus. |
| |
| Keywords: | |
|
|
