Lead Tetraacetate Cleavage of Chiral Phenylglycinol Derived Secondary Amines Without Racemization |
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| Authors: | Mohamed K Mokhallalati Lendon N Pridgen |
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| Institution: | Synthetic Chemistry Department , Smith Kline Beecham Pharmaceuticals , Post Office Box 1539, King of Prussia, PA 19406-0939 |
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| Abstract: | Diastereomerically enriched N-(1,1-disubstituted methyl)(2 ‘-hydroxyl’-phenylethyl) amines were oxidatively converted to enantiomerically enriched primary disubstituted methylamines in excellent yields without racemization, using an improved lead tetraacerate (LTA) procedure. |
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