Formation of Chromene Analogs of Homophthalates: Investigation of Condensation Products Derived from 2-Hydroxybenzaldehydes and Diethyl 2-Pentenedicarboxylates |
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| Authors: | Seetharamaiyer Padmanabhan Kaustubh V Gavaskar David J Triggle |
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| Institution: | Departments of Biochemical Pharmacology and Medicinal Chemistry , School of Pharmacy, State University of New York at Buffalo , Buffalo, NY, 14260, USA |
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| Abstract: | Condensation of substituted 2-hydroxybenzaldehyde derivatives (1a-1) with diethyl 2-pentenedicarboxylate (2) in the presence of piperidine gave coumarin and / or chromene derivatives. Attempted reaction of 4-N,N-diethylamino-2-hydroxybenzaldehyde (1a) and 2-hydroxy-3-nitrobenzaldehyde (1i) with diethyl 3-phenyl-2-pentenedicarboxylate (5) led to formation of no coumarin or chromene derivative. |
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