Synthesis of Regiospecific Chlorine-37 Labeled Trichlorodibenzofuran

2,3,4-Trichlorodibenzofuran was synthesized by converting 3-aminodibenzofuran to 3-amino-2,4-dichlorodibenzofuran using chlorine-saturated carbon tetrachloride, followed by diazotization of the amino group and displacement of the nitrogen by treatment with cuprous chloride. This method was used for the regiospecific synthesis of 2,3(³⁷Cl),4-trichlorodibenzofuran. NOE experiments were conducted to determine the final product.