Preparation of Hydrazides Using Silicon Tetrachloride as Coupling Agent1 |
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| Authors: | Milton J Kornet Terence T Tita P Alan |
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| Institution: | Thio College of Pharmacy and Division of Regulatory Services University of Kentucky , Lexington, Kentucky, 40506 |
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| Abstract: | Silicon tetrachloride proved to be an effective reagent for the preparation of hydrazides from carboxylic acids. Yields were comparable to those obtained via N,N′-dicyclohexylcarbodiimide (DCC) and the procedure was used to synthesize some hydrazides which are difficult to obtain otherwise. |
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