An Intramolecular Diels-alder Reaction of a Z-Diene. Generation Of The Chiral Isoindolone Nucleus Of Cytochalasin C.1 |
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Authors: | M. J. Hensel J. T. Palmer K. S. Learn P. L. Fuchs |
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Affiliation: | Department of Chemistry , Purdue University , West Lafayette, IN, 47907 |
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Abstract: | Aldol/elimination reactions of ß-ketoamides with methyl glyoxylate result in highly selective production of Z-α,ß-unsaturated amides. An intramolecular Diels-Alder reaction of a triply activated dienophile derived from chiral dienylamine 7ZE stereospecifically affords chiral bicyclic lactam 11 at room temperature. |
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