Synthesis of Isopropyl and Tert-butyl Pyridyl Ketones by Alkylation of Acetylpyridines with Methyl Iodide Using Phase Transfer Catalysis |
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| Authors: | K Rubina Yu Goldberg M Shymanska |
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| Institution: | Institute of Organic Synthesis, Latvian SSR Academy of Sciences , Riga , 226006 , USSR |
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| Abstract: | Isomeric acetylpyridines undergo regiospecific alkylation with methyl iodide under solid/liquid phase transfer conditions (aromatic solvent/KOH/18-crown-6) to give the corresponding isopropyl and/or tert-butyl pyridyl ketones, depending on reaction conditions. |
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