The Synthesis of Substituted 2-Aminophenyl Heterocyclic Ketones |
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| Authors: | R I Fryer P Zhang R Rios |
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| Institution: | Department of Chemistry Rutgers , The State University of New Jersey , 73 Warren Street, Newark, NJ, 07102 |
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| Abstract: | The synthesis of substituted 2-aminophenyl heterocyclic ketones, key intermediates to the preparation of 1,4-benzodiazepines has been achieved in one step and in good, yield from the corresponding anthranilic acid, by treatment with heterocyclic lithium reagents and chlorotrimethylsilane. |
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