Unsymmetrically Substituted Aliphatic Diacetylenes Containing Amine Functionalities |
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| Authors: | Rafael Rodriguez-Abad John Tsibouklis |
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| Institution: | 1. Departmento de Quimica Inorganica , Universidad Complutense , Madrid, 28040, Spain;2. University of Portsmouth, School of Pharmacy and Biomedical Sciences , St Michaels Building, White Swan Road, Portsmouth, PO1 2DT, England, UK |
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| Abstract: | A one-pot reaction which combines the Cadiot-Chodkiewicz coupling reaction with the Gabriel synthesis of primary amines is evaluated as a means for the synthesis of unsymmetrically disubstituted aminodiacetylenes of the type CH2-(CH2)n-C≡C-C≡C-CH2-NH2 (n=2,3,4,5). |
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