Convenient Synthesis of 2-Vinylindoles |
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| Authors: | R S Mali S G Tilve |
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| Institution: | Garware Research Centre Department of Chemistry , University of Poona , Pune, 411 007, India |
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| Abstract: | A convenient, two-step synthesis of 2-vinylindoles is described from the easily accessible (E)-ethyl-α-allyl-2-nitrocinnamates. Ethylcinnamates (1a and 1b) on reaction with triethylphosphite provide ethyl-2-allylindole-3carboxylates (2a and 2b ) along with minor amounts of their N-ethoxyderivatives (4a and 4b). Alkaline hydrolysis of 2a and 2b provide (E)-2-vinylindoles 3a and 3b in 60 and 67% yield respectively. |
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| Keywords: | Cyclofunctionalization Dihydropyrroles β-Enamino esters |
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