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Thermal Cleavage of Oxazolidine-4,5-diones to Imines: A Short Synthesis of 3,4-Dihydro-3,3-dimethyl-7-trifluoromethylisoquinoline-2-oxide |
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| Authors: | Ronald C Bernotas Ginette Adams Thaddeus R Nieduzak |
| Institution: | Hoechst Marion Roussel , 2110 E. Galbraith Road, Cincinnati, OH, 45215 |
| Abstract: | A series of oxazolidine-4,5-diones 2 was thermally cleaved to cyclic imines 3 in excellent yield. This reaction was utilized in an efficient synthesis of a 3,4-dihydroisoquinoline-based nitrone 1b. |
| Keywords: | |