Enantioselective Deprotonation of Cyclohexene Oxide to (R)-2-Cyclohexen-1-ol |
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| Authors: | Debnath Bhuniya Vinod K Singh |
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| Institution: | 1. Department of Chemistry , Indian Institute of Technology , Kanpur, India , 208 016;2. Department of Chemistry , Indian Institute of Technology , Kanpur, India , 208 016 |
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| Abstract: | The reaction of cyclohexene oxide with homochiral lithium amides, prepared from (S)-phenylglycine and (S)-valine has been studied and (R)-2-cyclohexen-1-ol 3 was prepared in a maximum of 72% ee. The optical purity was determined by 1H NMR measurement of the α-methoxy-α-(trifluoromethyl)phenyl acetic acid (MTPA) derivative of the corresponding alcohol. |
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