The Facile Synthesis of Dialkyl 1-Aminoalkylphosphonates |
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Authors: | Artur Ryglowski Pawer Kafarski |
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Institution: | Institute of Organic Chemistry, Biochemistry and Biotechnology, Technical University of Wroclaw , 50-370, Wroclaw, Poland |
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Abstract: | During past several years we have been engaged in the synthesis of phosphono peptides, peptide analogues with phosphonic acid replacing C-terminal carboxylate moiety. They became increasingly important since they appeared useful as carriers of toxic aminoalkylphosphonic acids through bacterial cell wall1–4 or into plant tissues.1,5 The most succesful method for the synthesis of these peptides is the condensation of N-blocked amino acids with dialkyl 6,7 or diphenyl 8.9 esters of aminoalkylphosphonic acids followed by removal of protecting groups. |
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