Alkoxide-Induced Reaction of 1-[(Trimethylsilyl)-Methyl]Azoles with Imines and Carbonyl Compounds |
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| Authors: | Sumio Shimizu Masaru Ogata |
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| Institution: | 1. Shionogi Research Laboratories, Shionogi &2. Co., Ltd. , Fukushima-ku, Osaka, 553, Japan |
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| Abstract: | t-BuOK-induced reaction of 1-(trimethylsilyl)methyl]-1,2,4-triazole with imines to yield (triazol-1- yl)ethylamines and (triazol-5-yl)methylamines was explored. Also, alkoxide-induced desilylation of 1-(trimethylsilyl)methyl]azoles in the presence of carbonyl compounds was demonstrated, and (-BuOK and potassium trimethylsilanolate were found to be effective in this reaction. |
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